Home > Search Results: keywords:"maternal separation"
Search:
Search Tips :: Advanced Search
Search collections:
Sort by: Display results: Output format:
National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Maternal separation and its impact on neurotransmitter systems of the brain
 Přítulová, Eliška ; Novotný, Jiří (advisor) ; Černá, Barbora (referee)
Adverse early life stress conditions during the postnatal period can alter normal brain and neuroendocrine system development and increase the susceptibility of the individual to various disorders. Material separation is a model used to investigate the effects of early life stress on organism. The principle of this model is to provoke the stress of the infant by disrupting its contact with the mother, which is important for its proper development. The aim of this paper is to unify the existing knowledge about the impact of maternal separation on signaling pathways in the brain and to outline the directions of future research. Despite all the differences between the individual studies, there is a basic finding that maternal separation leads to deficits in the functions of important neurotransmitter systems, can induce long-term changes in different brain signaling pathways and can be accompanied by changes at the neuroendocrine and behavioral levels.
Detailed record
Analysis of oxidative stress markers in rat brain: the effect of maternal separation
 Pallag, Gergely ; Novotný, Jiří (advisor) ; Vodička, Martin (referee)
Adverse events that cause stress during the early stages of life may alter the normal development of the brain and neuroendocrine system and increase the vulnerability of the individual to various disorders. Chronic stress and subsequent releasing of stress mediators can lead to oxidative stress and cell damage. The first aim of this work was to determine selected oxidative stress markers in the cerebral cortex, hippocampus, and cerebellum after the exposure of rats to early life stress. To model the stressful situation, we used maternal separation of the offspring for three hours a day during the first three weeks of life. We choose reduced glutathione, protein carbonyls, lipid peroxides and hydroperoxides as typical markers. These markers were determined in the brains of rats aged 22 days. Any significant changes were found in the levels of the studied markers after maternal separation. Damage to brain cells may also be reflected in behavior. Studies of numerous neuropsychiatric and neurodegenerative diseases have indicated that oxidative stress is a promising candidate for inducing changes at the cellular level. The second aim of this work was to monitor the behavior of rats by the light/dark box test after maternal separation along with administration of N-acetylcysteine (NAC), a drug with...
Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.
Digital Repository :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.2
Maintained by admin.invenio@techlib.cz
This site is also available in the following languages:
Česky  English